Clinical Trials

{
  "url": "https://clinicaltrials.gov/study/NCT02465060",
  "title": "Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)",
  "nct_id": "NCT02465060",
  "phases": [
    "PHASE2"
  ],
  "source": "clinicaltrials.gov",
  "status": "ACTIVE_NOT_RECRUITING",
  "conditions": [
    "Advanced Lymphoma",
    "Advanced Malignant Solid Neoplasm",
    "Bladder Carcinoma",
    "Breast Carcinoma",
    "Cervical Carcinoma",
    "Colon Carcinoma",
    "Colorectal Carcinoma",
    "Endometrial Carcinoma",
    "Esophageal Carcinoma",
    "Exocrine Pancreas Carcinoma"
  ],
  "enrollment": 6452,
  "study_type": "INTERVENTIONAL",
  "lead_sponsor": "National Cancer Institute (NCI)",
  "published_at": "2026-07-30T00:00:00.000Z",
  "interventions": [
    {
      "name": "Adavosertib",
      "type": "DRUG"
    },
    {
      "name": "Afatinib",
      "type": "DRUG"
    },
    {
      "name": "Afatinib Dimaleate",
      "type": "DRUG"
    },
    {
      "name": "Binimetinib",
      "type": "DRUG"
    },
    {
      "name": "Biopsy Procedure",
      "type": "PROCEDURE"
    },
    {
      "name": "Biospecimen Collection",
      "type": "PROCEDURE"
    },
    {
      "name": "Capivasertib",
      "type": "DRUG"
    },
    {
      "name": "Computed Tomography",
      "type": "PROCEDURE"
    },
    {
      "name": "Copanlisib",
      "type": "DRUG"
    },
    {
      "name": "Copanlisib Hydrochloride",
      "type": "DRUG"
    }
  ],
  "sponsor_class": "NIH",
  "official_title": "Molecular Analysis for Therapy Choice (MATCH)",
  "first_posted_at": "2015-06-08T00:00:00.000Z"
}

{
  "url": "https://clinicaltrials.gov/study/NCT05256225",
  "title": "Testing the Addition of Herceptin Hylecta or Phesgo to the Usual Chemotherapy for HER2 Positive Endometrial Serous Carcinoma or Carcinosarcoma",
  "nct_id": "NCT05256225",
  "phases": [
    "PHASE3"
  ],
  "source": "clinicaltrials.gov",
  "status": "RECRUITING",
  "conditions": [
    "Endometrial Carcinoma",
    "Endometrial Clear Cell Adenocarcinoma",
    "Endometrial Dedifferentiated Carcinoma",
    "Endometrial Endometrioid Adenocarcinoma",
    "Endometrial Mixed Cell Adenocarcinoma",
    "Endometrial Serous Adenocarcinoma",
    "Endometrial Undifferentiated Carcinoma",
    "Uterine Corpus Malignant Mixed Mesodermal (Mullerian) Tumor"
  ],
  "enrollment": 360,
  "study_type": "INTERVENTIONAL",
  "lead_sponsor": "National Cancer Institute (NCI)",
  "published_at": "2026-07-30T00:00:00.000Z",
  "interventions": [
    {
      "name": "Biospecimen Collection",
      "type": "PROCEDURE"
    },
    {
      "name": "Carboplatin",
      "type": "DRUG"
    },
    {
      "name": "Computed Tomography",
      "type": "PROCEDURE"
    },
    {
      "name": "Echocardiography Test",
      "type": "PROCEDURE"
    },
    {
      "name": "High-Dose-Rate Vaginal Cuff Brachytherapy",
      "type": "RADIATION"
    },
    {
      "name": "Hyaluronidase-zzxf/Pertuzumab/Trastuzumab",
      "type": "DRUG"
    },
    {
      "name": "Multigated Acquisition Scan",
      "type": "PROCEDURE"
    },
    {
      "name": "Paclitaxel",
      "type": "DRUG"
    },
    {
      "name": "Survey Administration",
      "type": "OTHER"
    },
    {
      "name": "Trastuzumab/Hyaluronidase-oysk",
      "type": "DRUG"
    }
  ],
  "sponsor_class": "NIH",
  "official_title": "A Phase II/III Study of Paclitaxel/Carboplatin Alone or Combined With Either Trastuzumab and Hyaluronidase-oysk (HERCEPTIN HYLECTA) or Pertuzumab, Trastuzumab, and Hyaluronidase-zzxf (PHESGO) in HER2 Positive, Stage I-IV Endometrial Serous Carcinoma or Carcinosarcoma",
  "first_posted_at": "2022-02-25T00:00:00.000Z"
}

{
  "url": "https://clinicaltrials.gov/study/NCT07173803",
  "title": "The Progressive Supranuclear Palsy Clinical Trial Platform",
  "nct_id": "NCT07173803",
  "phases": [
    "PHASE2"
  ],
  "source": "clinicaltrials.gov",
  "status": "NOT_YET_RECRUITING",
  "conditions": [
    "Progressive Supranuclear Palsy(PSP)"
  ],
  "enrollment": 440,
  "study_type": "INTERVENTIONAL",
  "lead_sponsor": "Adam Boxer",
  "published_at": "2026-07-30T00:00:00.000Z",
  "interventions": [
    {
      "name": "AADvac1",
      "type": "BIOLOGICAL"
    },
    {
      "name": "LM11A-31",
      "type": "DRUG"
    }
  ],
  "sponsor_class": "OTHER",
  "official_title": "The Progressive Supranuclear Palsy Clinical Trial Platform",
  "first_posted_at": "2025-09-15T00:00:00.000Z"
}

{
  "url": "https://clinicaltrials.gov/study/NCT07734909",
  "title": "Effectiveness of Combined Diaphragm Strengthening and Core Stability Exercises in Individuals With Lumbar Instability",
  "nct_id": "NCT07734909",
  "phases": [
    "NA"
  ],
  "source": "clinicaltrials.gov",
  "status": "NOT_YET_RECRUITING",
  "conditions": [
    "Lumbar"
  ],
  "enrollment": 30,
  "study_type": "INTERVENTIONAL",
  "lead_sponsor": "Cairo University",
  "published_at": "2026-07-29T00:00:00.000Z",
  "interventions": [
    {
      "name": "Diaphragm strengthening",
      "type": "OTHER"
    },
    {
      "name": "Core stability exercises",
      "type": "OTHER"
    }
  ],
  "sponsor_class": "OTHER",
  "official_title": "Effectiveness of Combined Diaphragm Strengthening and Core Stability Exercises in Individuals With Lumbar Instability",
  "first_posted_at": "2026-07-29T00:00:00.000Z"
}

{
  "url": "https://clinicaltrials.gov/study/NCT07732530",
  "title": "Acupoint Stimulation and Exercise for Taiwanese Pre-frail Older Adults",
  "nct_id": "NCT07732530",
  "phases": [
    "NA"
  ],
  "source": "clinicaltrials.gov",
  "status": "RECRUITING",
  "conditions": [
    "Frailty",
    "Sleep Quality",
    "Aging"
  ],
  "enrollment": 30,
  "study_type": "INTERVENTIONAL",
  "lead_sponsor": "Tainan Hospital, Ministry of Health and Welfare",
  "published_at": "2026-07-29T00:00:00.000Z",
  "interventions": [
    {
      "name": "Vivifrail Exercise Program",
      "type": "BEHAVIORAL"
    },
    {
      "name": "Acupoint Stimulation",
      "type": "OTHER"
    }
  ],
  "sponsor_class": "OTHER",
  "official_title": "Exploring the Associations Among Frailty, Daily Physical Activity, Sleep, and Traditional Chinese Medicine Constitution in Taiwanese Older Adults, and Evaluating the Effects of Acupoint Stimulation Interventions",
  "first_posted_at": "2026-07-29T00:00:00.000Z"
}

{
  "url": "https://clinicaltrials.gov/study/NCT05112601",
  "title": "Testing Nivolumab With or Without Ipilimumab in Deficient Mismatch Repair System (dMMR) Recurrent Endometrial Carcinoma",
  "nct_id": "NCT05112601",
  "phases": [
    "PHASE2"
  ],
  "source": "clinicaltrials.gov",
  "status": "RECRUITING",
  "conditions": [
    "Endometrial Adenocarcinoma",
    "Endometrial Clear Cell Adenocarcinoma",
    "Endometrial Dedifferentiated Carcinoma",
    "Endometrial Endometrioid Adenocarcinoma",
    "Endometrial Mixed Cell Adenocarcinoma",
    "Endometrial Mucinous Adenocarcinoma",
    "Endometrial Undifferentiated Carcinoma",
    "Endometrioid Adenocarcinoma",
    "Recurrent Endometrial Carcinoma"
  ],
  "enrollment": 81,
  "study_type": "INTERVENTIONAL",
  "lead_sponsor": "National Cancer Institute (NCI)",
  "published_at": "2026-07-29T00:00:00.000Z",
  "interventions": [
    {
      "name": "Biospecimen Collection",
      "type": "PROCEDURE"
    },
    {
      "name": "Computed Tomography",
      "type": "PROCEDURE"
    },
    {
      "name": "Ipilimumab",
      "type": "BIOLOGICAL"
    },
    {
      "name": "Magnetic Resonance Imaging",
      "type": "PROCEDURE"
    },
    {
      "name": "Nivolumab",
      "type": "BIOLOGICAL"
    }
  ],
  "sponsor_class": "NIH",
  "official_title": "A Randomized Phase II Trial of Nivolumab and Ipilimumab Compared to Nivolumab Monotherapy in Patients With Deficient Mismatch Repair System Recurrent Endometrial Carcinoma",
  "first_posted_at": "2021-11-09T00:00:00.000Z"
}

{
  "url": "https://clinicaltrials.gov/study/NCT07734727",
  "title": "Adaptation and Testing of a Novel Text-based Tobacco Cessation and Education Intervention in Kenyan Emergency Department Patients",
  "nct_id": "NCT07734727",
  "phases": [
    "NA"
  ],
  "source": "clinicaltrials.gov",
  "status": "NOT_YET_RECRUITING",
  "conditions": [
    "Tobacco Use",
    "Tobacco Use Cessation"
  ],
  "enrollment": 285,
  "study_type": "INTERVENTIONAL",
  "lead_sponsor": "Yale University",
  "published_at": "2026-07-29T00:00:00.000Z",
  "interventions": [
    {
      "name": "Text2Quit-Kenya",
      "type": "OTHER"
    }
  ],
  "sponsor_class": "OTHER",
  "official_title": "Adaptation and Testing of a Novel Text-based Tobacco Cessation and Education Intervention in Kenyan Emergency Department Patients",
  "first_posted_at": "2026-07-29T00:00:00.000Z"
}

{
  "url": "https://clinicaltrials.gov/study/NCT04987060",
  "title": "Intrastromal Fresh Human Corneal Lenticule Implantation Using Smile Surgery for Treatment of Irregular Corneal Astigmatism After Penetrating Keratoplasty (New Approach)",
  "nct_id": "NCT04987060",
  "phases": [
    "NA"
  ],
  "source": "clinicaltrials.gov",
  "status": "ACTIVE_NOT_RECRUITING",
  "conditions": [
    "Irregular Astigmatism"
  ],
  "enrollment": 24,
  "study_type": "INTERVENTIONAL",
  "lead_sponsor": "Eye Hospital Pristina Kosovo",
  "published_at": "2026-07-29T00:00:00.000Z",
  "interventions": [
    {
      "name": "Intrastromal Fresh Human Lenticule Implantation",
      "type": "DEVICE"
    }
  ],
  "sponsor_class": "OTHER",
  "official_title": "Intrastromal Fresh Human Corneal Lenticule Implantation Using Smile Surgery for Treatment of Irregular Corneal Astigmatism After Penetrating Keratoplasty (New Approach)",
  "first_posted_at": "2021-08-03T00:00:00.000Z"
}

{
  "url": "https://clinicaltrials.gov/study/NCT07733310",
  "title": "Augmented Depression Therapy (ADepT) Case Series",
  "nct_id": "NCT07733310",
  "phases": [
    "NA"
  ],
  "source": "clinicaltrials.gov",
  "status": "NOT_YET_RECRUITING",
  "conditions": [
    "Depression / Major Depressive Disorder"
  ],
  "enrollment": 40,
  "study_type": "INTERVENTIONAL",
  "lead_sponsor": "Ohio State University",
  "published_at": "2026-07-29T00:00:00.000Z",
  "interventions": [
    {
      "name": "Augmented Depression Therapy (ADepT)",
      "type": "BEHAVIORAL"
    }
  ],
  "sponsor_class": "OTHER",
  "official_title": "Augmented Depression Therapy (ADepT) Case Series",
  "first_posted_at": "2026-07-29T00:00:00.000Z"
}

{
  "url": "https://clinicaltrials.gov/study/NCT07733141",
  "title": "Mindfulness Intervention to Reduce Patient Reported Symptoms in Patients With Chronic Graft-Versus-Host Disease",
  "nct_id": "NCT07733141",
  "phases": [
    "NA"
  ],
  "source": "clinicaltrials.gov",
  "status": "NOT_YET_RECRUITING",
  "conditions": [
    "Chronic Graft Versus Host Disease",
    "Hematopoietic and Lymphatic System Neoplasm",
    "Malignant Solid Neoplasm"
  ],
  "enrollment": 17,
  "study_type": "INTERVENTIONAL",
  "lead_sponsor": "City of Hope Medical Center",
  "published_at": "2026-07-29T00:00:00.000Z",
  "interventions": [
    {
      "name": "Biospecimen Collection",
      "type": "PROCEDURE"
    },
    {
      "name": "Mindfulness Relaxation",
      "type": "BEHAVIORAL"
    },
    {
      "name": "Mindfulness Relaxation",
      "type": "BEHAVIORAL"
    },
    {
      "name": "Mindfulness Relaxation",
      "type": "BEHAVIORAL"
    },
    {
      "name": "Survey Administration",
      "type": "OTHER"
    }
  ],
  "sponsor_class": "OTHER",
  "official_title": "Pilot Feasibility Study of Mindfulness-Based Intervention in Patients With Chronic Graft-Versus-Host Disease",
  "first_posted_at": "2026-07-29T00:00:00.000Z"
}